The relative configuration of N 5 -methyl-L -tetrahydrofolic acid
نویسندگان
چکیده
منابع مشابه
5-Methyl-5,6,7,8-tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring.
It is suggested from analysis of proton spin-spin coupling constants that the tetrahydropyrazine ring of 5methyltetrahydrofolate in solution is in a half-chair conformation, with the methyl group at N-5 and the methylene group C-9 truns, and with C-6-H in an equatorial position. The chemical shifts and spin-spin coupling constants for the carbon-bound hydrogens of (+)-L-, (-)-L, (+)-L-~-‘H, 7-‘...
متن کاملThe threshold growth response of Lactobacillus casei to 5-methyl-tetrahydrofolic acid: implications for folate assays.
The comparative and absolute growth response of Lactobacillus casei was measured nephelometrically for time periods of 17-23 h in the microbiological assay of folic acid and 5-methyl-tetrahydrofolic acid at concentrations of 0-8 ng/10 ml basal medium at pH 6.8. At concentrations of 0-1 ng/10 ml the comparative growth response to 5-methyl-tetrahydrofolic acid was markedly depressed whereas growt...
متن کاملEnzymic preparation of the 1,L-diastereoisomer of tetrahydrofolic acid.
hydrogenation of folic acid in an acidic or neutral medium (Z-5)) and this process, involving a reduction of the pyrazine ring, introduces a second asymmetric center1 (at carbon 6) into the molecule. Since chemically synthesized tetrahydrofolate is a &mixture with reference to this center, only 50 To of the material is utilized in reactions in which it serves as a coenzyme (7-10). Accordingly, ...
متن کاملThe dissociation constants of tetrahydrofolic acid.
Six dissociable groups exist in tetrahydrofolic acid in the range Ho -3.0 to pH 14. The assignments in tetrahydrofolic acid by titrimetric and spectrophotometric comparisons with model compounds, +uninobenzoylglutamic acid and 2-amino-6,7-dimethyl-5,6,7,8-tetrahydro-4-pteridinone, are as follows: acidic ionization of amide, pK’ 10.5; Ns, pK’ 4.82; y-carboxyl, pK’ 4.8; cr-carboxyl, pK’ 3.5; N1, ...
متن کاملN-{N-[N-(1,1-Dimethylethoxycarbonyl)-l-leucyl]-N-methyl-l-leucyl}-N-methyl-l-leucine benzyl ester
The tripeptide title compound, C(32)H(53)N(3)O(6), synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxy-carbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyl-oxycarbonyl group at the C-tip and a benzyl group at the N-tip. A classical inter-molecular N-H⋯O hydrogen bond and a weak ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1970
ISSN: 0014-5793
DOI: 10.1016/0014-5793(70)80544-0